EB-47 (dihydrochloride)
CAS No. : 1190332-25-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $250 | In-stock |
| 50mg | $780 | In-stock |
| 100mg | $1300 | In-stock |
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| Cat. No. : | HY-108631 |
| M.Wt: | 610.45 |
| Formula: | C24H29Cl2N9O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic);H2O : 33.33 mg/mL (ultrasonic) |
EB-47 dihydrochloride, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM. EB-47 mimics the substrate NAD+?and extends from the nicotinamide to the adenosine subsite[1]. In Vitro: EB-47 dihydrochloride shows inhibition in excess of 50% with CdPARP, and it is able to inhibit CdPARP and HsPARP with IC50 values of 0.86 and 1.0?μM, respectively[1]. In Vivo: EB-47 dihydrochloride (2 μM; 5 days) decreases the number of embryo implantation sites and blastocysts at day 5. PARP1 participates in the process of embryo implantation[3].
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