PF-4800567
CAS No. : 1188296-52-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $130 | In-stock |
| 25mg | $280 | In-stock |
| 50mg | $410 | In-stock |
| 100mg | $590 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12470 |
| M.Wt: | 359.81 |
| Formula: | C17H18ClN5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic;warming;heat to 60°C) |
PF-4800567 is a potent and selective inhibitor of casein kinase 1? (CK1?), with an IC50 of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM). IC50 & Target:IC50: 32 nM (CK1?), 711 nM (CK1δ)[1] In Vitro:PF-4800567 is a potent and selective inhibitor of casein kinase 1 (CK1), with an IC50 of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM). PF-4800567 shows inhibitory activity against CK1ε and CK1δ in whole cells, with IC50s of 2.65 and 20.38 μM, respectively. PF-4800567 (0.01-10 μM) blocks CK1ε-mediated PER3 nuclear localization and suppresses PER2 degradation at 1 μM. In addition, PF-4800567 has little effect on the circadian clock at 32 nM[1]. In Vivo:PF-4800567 (100 mg/kg, s.c.) is rapidly absorpted and distributed in plasma and brain of mice[1].
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- Cat. No.:
- HY-12470
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