TIK-301
CAS No. : 118702-11-7
(Synonyms: PD-6735; LY-156735)
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| Cat. No. : | HY-106136 |
| M.Wt: | 280.75 |
| Formula: | C14H17ClN2O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT1 and MT2 receptors agonist with Kis of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a 5-HT2B/5-HT2C receptors antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment[1][2][3].
In Vivo: In male rats, TIK-301(at doses of 0.8 and 4.0 mg/kg/day) can reduce body weight, and without altering food intake[1][2].
The Tmax and half-life of TIK-301 is 1.1 hour and 1 hour, respectively[1].
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