ML-109


CAS No. : 1186649-91-1

1186649-91-1
Price and Availability of CAS No. : 1186649-91-1
Size Price Stock
5mg $90 In-stock
10mg $150 In-stock
25mg $300 In-stock
50mg $490 In-stock
100mg $790 In-stock
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Cat. No. : HY-114116
M.Wt: 523.58
Formula: C31H29N3O5
Purity: >98 %
Solubility: DMSO : 83.33 mg/mL (ultrasonic)
Introduction of 1186649-91-1 :

ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC50 of 40 nM. IC50 & Target: EC50: 40 nM (TSHR)[1]. In Vitro: ML-109 (Compound 2) is a full agonist at TSHR with an EC50 of 40 nM and, like compound 1, it has no activity at FSHR or LHCGR. ML-109 contains an aminal, a functional group that is subject to hydrolysis and/or other degradation mechanisms. ML-109 is surprisingly stable at neutral and basic conditions (t1/2 of ~16 h) but is found to degrade at low pH (t1/2 of ~3 h)[1].

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