MK2-IN-3 (hydrate)
CAS No. : 1186648-22-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $100 | In-stock |
| 5mg | $200 | In-stock |
| 10mg | $320 | In-stock |
| 25mg | $640 | In-stock |
| 50mg | $1020 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-112457 |
| M.Wt: | 358.39 |
| Formula: | C21H18N4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
MK2-IN-3 hydrate (compound 16) is an orally active, selective, and ATP-competitive MAPKAP-K2 (MK-2) inhibitor with an IC50 of 8.5 nM.MK2-IN-3 hydrate is exceptional selectivity against MK-3 (IC50=0.21 μM), MK-5 (IC50=0.081 μM), ERK2 (IC50=3.44 μM), MNK1(IC50=5.7 μM) as well as CDK2, JNK2, IKK2, MSK1, and MSK2[1]. IC50 & Target:IC50: 8.5 nM (MK-2), 0.21 μM (MK-3), 0.081 μM (MK-5), 3.44 μM (ERK2), 5.7 μM (MNK1)[1] In Vitro:MK2-IN-3 hydrate suppresses TNFα production in U397 cells with an IC50 of 4.4 μM[1].
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