Lu AE51090
CAS No. : 1186229-95-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $235 | In-stock |
| 10mg | $380 | In-stock |
| 25mg | $735 | In-stock |
| 50mg | $1150 | In-stock |
| 100mg | $1800 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-118363 |
| M.Wt: | 407.51 |
| Formula: | C24H29N3O3 |
| Purity: | >98 % |
| Solubility: |
Lu AE51090 is selective muscarinic M1 receptor agonist with blood-brain barrier penetration. Lu AE51090 activates human M1 receptor with EC50 of 61 nM, while showing no significant agonism at M2-M5 receptors. Lu AE51090 exerts procognitive effects in mice. Lu AE51090 can be used for the study of Alzheimer’s disease (AD) and cognitive impairment associated with schizophrenia (CIAS)[1].
In Vitro:Lu AE51090 (up to 10 μM) exhibits agonistic activity at human M1 receptor (EC50 = 61 nM, Emax = 83%) in Ca2+ mobilization assays using CHO-K1/BHK-21 cells expressing respective receptors[1].
In Vivo:Lu AE51090 (0.31-20 mg/kg, s.c., once, 30 min pre-experiment) exerts dose-dependent procognitive effects in male C57Bl/6J mice[1].
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