ALW-II-41-27
CAS No. : 1186206-79-0
(Synonyms: Eph receptor tyrosine kinase inhibitor)
| Size | Price | Stock |
|---|---|---|
| 5mg | $231 | In-stock |
| 10mg | $323 | In-stock |
| 25mg | $500 | In-stock |
| 50mg | $700 | In-stock |
| 100mg | $980 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-18007 |
| M.Wt: | 607.69 |
| Formula: | C32H32F3N5O2S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 47 mg/mL |
ALW-II-41-27 is a Eph family tyrosine kinase inhibitor with an IC50 of 11 nM for Eph2. IC50 & Target: IC50: 11 nM (Eph2)[1] In Vitro: ALW-II-41-27 inhibits Ba/F3 cells transformed with Tel fusions of EphA3, Kit, Fms, KDR, FLT1, FGR, Src, Lyn, Bmx, and Bcr-Abl with an EC50?below 500 nM. ALW-II-41-27 exhibits cross reactivity with Bcr-Abl. ALW-II-41-27 inhibits b-raf, CSF1R, DDR1, DDR2, EphA2, EphA5, EphA8, EphB1, EphB2, EphB3, Frk, Kit, Lck, p38α, p38β, PDGFRα, PDGFRβ, and Raf1 and many more demonstrating how introduction of the thiophene group can have a tremendous impact on kinase selectivity[1].
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