MTEP (hydrochloride)
CAS No. : 1186195-60-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $72 | In-stock |
| 10mg | $112 | In-stock |
| 25mg | $251 | In-stock |
| 50mg | $390 | In-stock |
| 100mg | $600 | In-stock |
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| Cat. No. : | HY-13206 |
| M.Wt: | 236.72 |
| Formula: | C11H9ClN2S |
| Purity: | >98 % |
| Solubility: | H2O : 20 mg/mL (ultrasonic) |
MTEP hydrochloride is a potent, non-competitive and highly selective mGluR5 antagonist, with an IC50 of 5 nM and a Ki of 16 nM. MTEP hydrochloride shows antidepressant and anxiolytic-like effects. MTEP hydrochloride can be used for Parkinson's disease research[1][2][3][4].
IC50 & Target:IC50: 5 nM (mGluR5)[1]
Ki: 16 nM (mGluR5)[1]
In Vitro:MTEP shows highly selective for mGluR5 over mGluR1, has no effect on other mGluR subtypes, and has fewer off-target effects than MPEP (HY-14609A)[1].
In Vivo:MTEP (0-5 mg/kg, i.p., once) inhibits the catalepsy induced by Haloperidol (HY-14538) (0.5 mg/kg/2 ml i.p.)[2].
MTEP (0.3-3 mg/kg, intraperitoneal injection, once) induces antidepressant-like effects in male C57BL/6J mice[3].
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