UNC926
CAS No. : 1184136-10-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $59 | In-stock |
| 10mg | $98 | In-stock |
| 25mg | $190 | In-stock |
| 50mg | $340 | In-stock |
| 100mg | $550 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16510 |
| M.Wt: | 337.25 |
| Formula: | C16H21BrN2O |
| Purity: | >98 % |
| Solubility: | DMSO : 41.67 mg/mL (ultrasonic;warming;heat to 60°C) |
UNC926 is a methyl-lysine (Kme) reader domain inhibitor that inhibits L3MBTL1 with an IC50 of 3.9 μM[1].
IC50 & Target: IC50: 3.9 μM (L3MBTL1), 3.2 μM (L3MBTL3), 15.6 μM (L3MBTL4)[1]
In Vitro: UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC50 of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7[1].
UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1[1].
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