Tyrphostin 25
CAS No. : 118409-58-8
(Synonyms: AG82; Tyrphostin A 25; Tyrphostin AG 82; RG-50875)
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| 10mg | $105 | In-stock |
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| Cat. No. : | HY-101958 |
| M.Wt: | 202.17 |
| Formula: | C10H6N2O3 |
| Purity: | >98 % |
| Solubility: |
Tyrphostin 25 (AG82) is a specific inhibitor of the EGFR tyrosine kinase with an IC50 value of 3 µM in A431 cells. Tyrphostin 25 is also a GPR35 agonist with an EC50 of 5.3 µM[1][2][3].
IC50 & Target:EGFR tyrosine kinase[1]
IC50: 0.94 µM (GPR35)[2]
EC50: 5.3 µM (GPR35)[2]
In Vitro:Tyrphostin 25 ((50 μM for 12-16 h) selectively prevents EGFR autophosphorylation thereby preventing the EGF-induced FG human pancreatic carcinoma cells migration response on vitronectin without affecting constitutive migration on collagen[1].
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