Tyrphostin 23


CAS No. : 118409-57-7

(Synonyms: Tyrphostin A23; RG-50810; AG 18)

118409-57-7
Price and Availability of CAS No. : 118409-57-7
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5mg $41 In-stock
10mg $66 In-stock
25mg $150 In-stock
50mg $260 In-stock
100mg $390 In-stock
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Cat. No. : HY-15644
M.Wt: 186.17
Formula: C10H6N2O2
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 118409-57-7 :

Tyrphostin 23 (Tyrphostin A23) is an EGFR inhibitor with an IC50 and Kiof 35 and 11 μM, respectively. IC50 & Target: IC50: 35 μM (EGFR)[1]

Ki: 11 μM

In Vitro: 10 μM tyrphostin 23 causes significant inhibition of the cell proliferation caused by 1 nM and 1μM ghrelin[2]. Tyrphostin 23 (T23) is a well-known inhibitor of protein tyrosine kinases and has been considered as potential anti-cancer drug. T23 is reported to acutely stimulate the glycolytic flux in primary cultured astrocytes. Tyrphostin 23 stimulates glycolytic flux in cultured astrocytes. Mitochondrial metabolism of brain astrocytes is accelerated by Tyrphostin 23 exposure[3].

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