SD-1029
CAS No. : 118372-34-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $148 | In-stock |
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| 10 mg | Get quote | |
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| Cat. No. : | HY-112391 |
| M.Wt: | 639.25 |
| Formula: | C25H32Br2Cl2N2O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
SD-1029 is a JAK2/STAT3 inhibitor[1]. SD-1029 inhibits STAT3 nuclear translocation. SD-1029 is an inhibitor of STAT3 activation due to inhibition of JAK2 phosphorylation[2].
In Vitro: SD-1029 (10 μM) inhibits EGFP-Stat3 nuclear translocation in BHK-21 and U-2OS cells[1].
SD-1029 (5 and 10 μM; 24 hours) inhibits cell growth and induces apoptosis in OVCAR8TR ovarian cancer cells[1].
SD-1029 (10 μM; 24 hours) suppresses p-Stat3 levels in human breast and ovarian cancer cell lines[1].
SD-1029 inhibits not only JAK2 phosphorylation, but also the phosphorylation of STAT1 and STAT3. SD-1029 strongly inhibits Tyk2 phosphorylation, implicating both JAK2 and Tyk2 as upstream requirements for IL-23-induced IL-23R expression[2].
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