Duocarmycin A
CAS No. : 118292-34-5
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| Cat. No. : | HY-12455 |
| M.Wt: | 507.49 |
| Formula: | C26H25N3O8 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels[1].
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