Lafutidine
CAS No. : 118288-08-7
(Synonyms: FRG-8813)
| Size | Price | Stock |
|---|---|---|
| 50mg | $30 | In-stock |
| 100mg | $48 | In-stock |
| 250mg | $97 | In-stock |
| 500mg | $166 | In-stock |
| 1g | $266 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-B0160 |
| M.Wt: | 431.55 |
| Formula: | C22H29N3O4S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
Lafutidine (FRG-8813) is a histamine H2-receptor antagonist (H2RA), with proven gastric mucosal protective effects. Lafutidine can be used for the research of gastroesophageal reflux disease[1].
IC50 & Target: Histamine H2-receptor[1]
In Vitro: Lafutidine exhibits gastric mucosal protective action mediated by capsaicin-sensitive afferent neurons, in addition to a potent antisecretory effect[2].
Lafutidine (0.1-10 µM) significantly augments the periarterial nerve stimulation (PNS, 1 Hz) induced-vasodilation in a concentration-dependent manner in rat perfused mesenteric vascular beds[2].
In Vivo: Lafutidine (3-30 mg/kg; p.o.; twice daily; for 6 days) dose-dependently reduces the severity of dextran sulfate Na (DSS)-induced colitis and significantly mitigates changes in the colon length and myeloperoxidase (MPO) activity[3].
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