Peruvoside
CAS No. : 1182-87-2
(Synonyms: Encordin)
| Size | Price | Stock |
|---|---|---|
| 1mg | $260 | In-stock |
| 5mg | $780 | In-stock |
| 10mg | $1320 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-108016 |
| M.Wt: | 548.66 |
| Formula: | C30H44O9 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Peruvoside is a potent inhibitor of Src, PI3K, JNK, STAT, and EGFR. Peruvoside induces apoptosis and autophagy and possesses a broad spectrum of anticancer activity in breast, lung, liver cancers and leukemia. Peruvoside is a broad-spectrum and potent antiviral activity against positive-sense RNA viruses. Peruvoside sensitizes Gefitinib (HY-50895)-resistant tumour cells (A549, PC9/gef and H1975) to Gefitinib[1][2][3][4].
In Vitro:Peruvoside (50-1000 nM, 24 h) inhibits the viability and proliferation in PC9, PC9/gef, H3255, and H1975 cell lines[1].
Peruvoside (0.005-0.5 μM, 72 h) sensitizes A549, PC9/gef and H1975 to Gefitinib when in combination with Gefitinib (0.01~0.5 μM)[1].
Peruvoside (0-100 μM, 24 h) induces cell cycle arrest and apoptosis in MCF-7, HpG2, and A549 cells[2.
In Vivo:Peruvoside (0.1 mg/kg for i.p; once daily for 28 days) suppresses the tumour growth in lung cancer mice model[1].
Peruvoside (0.59 mg/kg for i.p; once daily for 7 days) reduces mortality in EV-A71-infected mice model[4].
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