Soyasaponin Ab

Soyasaponin Ab is an orally active soyasaponin. Soyasaponin Ab inhibits PPARγ transcriptional activity. Soyasaponin Ab induces apoptosis in high concentrations. Soyasaponin Ab exerts anti-obesity, anti-oxidation, anti-inflammation, anti-aging effects. Soyasaponin Ab prevents Scopolamine (HY-N0296)-induced memory impairment^[1][2][3][4]. In Vitro:Soyasaponin Ab (25-100 μM, 8 days ) decreases triglyceride accumulation in a dose-dependent manner in 3T3-L1 adipocytes^[1].
Soyasaponin Ab (25-100 μM, 24 h) suppresses the transcriptional activity of peroxisome proliferator-activated receptor γ (PPARγ) in HEK 293T cells^[1].
Soyasaponin Ab (50-100 μM, 8 days ) markedly inhibits adipocyte differentiation and expression of various adipogenic marker genes (including adiponectin, ADD1/SREBP1c, aP2, Fas, and resistin) through the downregulation of the adipogenesis-related transcription factors PPARγ and C/EBPα in 3T3-L1 adipocytes^[1].
Soyasaponin Ab (1-100 μM, 1 h) shows concentration dependent inhibition of lipid peroxidation in liposomes (IC₅₀ = 14.5 μM)^[2].
Soyasaponin Ab (10-50 μM, 48 h) regulates translocation of Nrf2 and protein expressions of the phase II antioxidant enzyme HO-1 and NQO1, through the ERK1/2 signaling pathway in HepG2 cells^[2].
Soyasaponin Ab (1-400 μM, 48 h or 10 days) shows little toxicity below 50 μM and reduces the formation of colonies at the dose that above 50 μM and induces apoptosis in HepG2 cells^[2].
Soyasaponin Ab (1-10 μM, 16 h or 4 h) significantly reduces Lipopolysaccharides (LPS) (HY-D1056)-stimulated IL-1β, TNF-α and TLR4 expression and PGE₂ and NO production in peritoneal macrophages^[3].
In Vivo:Soyasaponin Ab (10-20 mg/kg; p.o.; daily for 5 days) shows inhibitory effect in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in male ICR mice^[3].
Soyasaponin Ab (5-40 mg/kg; p.o.; one hour before the trial) significantly prevents Scopolamine (HY-N0296)-induced memory impairment in male ICR mice^[4].