PS48
CAS No. : 1180676-32-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $150 | In-stock |
| 50mg | $220 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-15967 |
| M.Wt: | 286.75 |
| Formula: | C17H15ClO2 |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL (ultrasonic) |
PS48 is an activator of PDK1 with an AC50 of 8 μM. IC50 & Target:AC50: 8 μM (PDK1)[1] In Vitro:PDK1 activator, PS48, has the ability to reverse the cell proliferation inhibition role of Triptolide (HY-32735) in vitro. The inhibition role of Triptolide in cell number is significantly reversed by PS48. Triptolide significantly increases the cell proportion in G0-G1 phase and decreases the cell proportion in G2-M and S phase. However, the effect of Triptolide on cell cycle distribution is all reversed by PS48. In addition, suppression of PDK1/Akt/mTOR pathway by Triptolide in high glucose (HG)-treated human renal mesangial cells (HRMCs) is also reversed by PS48, as well as the expression of Ki-67 and proliferating cell nuclear antigen (PCNA)[2].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- PS48
- Cat. No.:
- HY-15967
- Quantity:
Your information is safe with us.