ITZ-1
CAS No. : 1180532-17-5
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| Cat. No. : | HY-120505 |
| M.Wt: | 541.58 |
| Formula: | C20H20F5N3O3S3 |
| Purity: | >98 % |
| Solubility: |
ITZ-1 is an orally active and selective extracellular signal-regulated kinase (ERK)-mitogen-activated protein kinase (MAPK) pathway inhibitor with an IC50 of 0.51 μM for inhibiting interleukin-1β (IL-1β)-induced matrix metalloproteinase-13 (MMP-13) production. ITZ-1 reduces MMP-13 expression and suppresses nitric oxide (NO)-induced chondrocyte apoptosi. ITZ-1 is promising for research of osteoarticular diseases[1].
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