Loreclezole
CAS No. : 117857-45-1
(Synonyms: R 72063)
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $90 | In-stock |
| 25mg | $180 | In-stock |
| 50mg | $270 | In-stock |
| 100mg | $385 | In-stock |
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| Cat. No. : | HY-105272 |
| M.Wt: | 274.53 |
| Formula: | C10H6Cl3N3 |
| Purity: | >98 % |
| Solubility: | DMSO : 110 mg/mL (ultrasonic) |
Loreclezole, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors[1][2]. IC50 & Target: GABAA receptor[1]. In Vivo: Loreclezole (10, 25, 50 or 75 mg/kg, i.p. 60 min before measurement of seizure threshold ) results in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. Loreclezole also has the least effect on loss of muscle tone as measured by the “pull-up” test[3].
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