NSC 23766 (trihydrochloride)
CAS No. : 1177865-17-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $66 | In-stock |
| 10mg | $105 | In-stock |
| 25mg | $190 | In-stock |
| 50mg | $350 | In-stock |
| 100mg | $513 | In-stock |
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| Cat. No. : | HY-15723A |
| M.Wt: | 530.96 |
| Formula: | C24H38Cl3N7 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic);H2O : ≥ 32 mg/mL |
NSC 23766 trihydrochloride is an inhibitor of Rac1 activation. In Vitro: NSC 23766 (100?μM) treatment effectively inhibits polar body emission in a dose-dependent manner. NSC 23766 (200 μM) increases the percentage of morphologically abnormal spindles of oocytes. In NSC 23766-treated oocytes, the p-MAPK protein expression is significantly decreased[2]. NSC23766 (50?μM) plus 100?ng/mL Jagged1, GDF9 and BMP15, reduces the number of germLine cell cysts and increases the number of primordial follicles[3]. NSC23766 significantly inhibits GTP-Rac1 activity and phosphorylation of Rac1-PAK, ERKs and p38 MAPK in the spinal dorsal horn neurons[4]. In Vivo: NSC23766 (2.5 mg/kg/day, i.p.) significantly attenuates the onset of spontaneous diabetes in NOD mice, without significant effects on the growth (body weights) of the mice. NSC23766 significantly increases the expression of Rac1 and CHOP, a marker for ER-stress, in islets from NOD mice[1].
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