3-Cyano-7-ethoxycoumarin
CAS No. : 117620-77-6
| Size | Price | Stock |
|---|---|---|
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| 250mg | $67 | In-stock |
| 1g | $180 | In-stock |
| 5g | $576 | In-stock |
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| Cat. No. : | HY-D0055 |
| M.Wt: | 215.20 |
| Formula: | C12H9NO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic) |
3-Cyano-7-ethoxycoumarin is a fluorescent cytochrome P-450 substrate that generates a blue fluorescent product upon enzymatic cleavage. 3-Cyano-7-ethoxycoumarin is used to detect the activity of mixed-function oxidases in isolated rat hepatocytes. 3-Cyano-7-ethoxycoumarin serves as a biological dye and indicator for research[1][2].
In Vitro:3-Cyano-7-ethoxycoumarin is metabolized by cytochrome P-450-dependent mixed-function oxidases in isolated rat hepatocytes[1].
3-Cyano-7-ethoxycoumarin exhibits fluorescent properties in neutral pH buffer solutions, with the maximum wavelengths of its excitation and emission peaks being 355 nm and 410 nm, respectively[1].
3-Cyano-7-ethoxycoumarin can be converted into 3-cyano-7-hydroxycoumarin, which exhibits fluorescence properties under neutral pH conditions, with maximum excitation and emission wavelengths of 408 nM and 450 nM, respectively[1].
3-Cyano-7-ethoxycoumarin serves as a fluorescent substrate that undergoes dealkylation by rat CYP1A1, human CYP1A1, and human CYP1A2 to produce a fluorescent product[2].
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