VER-00158411
CAS No. : 1174664-88-0
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| Cat. No. : | HY-18942 |
| M.Wt: | 538.64 |
| Formula: | C31H34N6O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
VER-00158411 is a checkpoint kinase 1 (CHK1) and CHK2 inhibitor with IC50 values of 4.4 nM and 4.5 nM, respectively[1]. In Vitro: Cellular sensing of DNA damage, along with concomitant cell cycle arrest, is mediated by a great many proteins and enzymes. One focus of pharmaceutical development has been the inhibition of DNA damage signaling, and checkpoint kinases (CHKs). There have been a number of clinical trial of checkpoint kinase inhibits alone or as a combination therapy for example, as a means to sensitize proliferating tumor cells to chemotherapies that damage DNA. The development of checkpoint kinase inhibitors the treatment of cancer was a major objective in drug discovery[1].
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