Midafotel
CAS No. : 117414-74-1
(Synonyms: SDZ-EAA 494)
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|---|---|---|
| 1mg | $240 | In-stock |
| 5mg | $600 | In-stock |
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| Cat. No. : | HY-107718 |
| M.Wt: | 250.19 |
| Formula: | C8H15N2O5P |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
D-CPP-ene (SDZ-EAA 494) is a potent and comprtitive NMDA antagonist with an ED50 value of 39 nM. D-CPP-ene causes intense stereotyped behaviors. D-CPP-ene shows neuroprotective effects[1][2][3].
In Vivo: D-CPP-ene (15 mg/kg; i.p.) causes intense stereotyped behaviors in rats[2].
D-CPP-ene (1.5, 4.5, 15 mg/kg; i.v.; initiated 15 min prior to MCA occlusion (followed by constant infusion at 1, 3 or 10 mg/kg/h)) produces dose-dependent reductions in the volumes of infarction; the dose of 4.5 mg/kg being the most effective in focal cerebral ischemia in the rat[3].
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