Endothelin 1 (swine, human)
CAS No. : 117399-94-7
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|---|---|---|
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| 1mg | $264 | In-stock |
| 5mg | $850 | In-stock |
| 10mg | $1360 | In-stock |
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| Cat. No. : | HY-P0202 |
| M.Wt: | 2491.90 |
| Formula: | C109H159N25O32S5 |
| Purity: | >98 % |
| Solubility: | H2O : 0.99 mg/mL (adjust pH to 2 with TFA);DMSO : 50 mg/mL (ultrasonic) |
Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB[1]. IC50 & Target:ETA and ETB[1] In Vitro: Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. It acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion[1].
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