Endothelin-3, human, mouse, rabbit, rat

Endothelin-3, human, mouse, rabbit, rat (Endothelin 3 (Rat,Human)) is an adhesion stimulant. Endothelin-3, human, mouse, rabbit, rat stimulates the adhesion of enteric neural crest cells to various ECM components. Endothelin-3, human, mouse, rabbit, rat plays an important role in the maintenance and self-renewal of intestinal progenitor cells, participates in the migration of enteric neural crest cells, and helps maintain a suitable environment for the colonization of enteric neural crest cells. Endothelin-3, human, mouse, rabbit, rat acts synergistically with the β1-integrin signaling pathway during enteric nervous system development. Endothelin-3, human, mouse, rabbit, rat can be used in studies related to distal aganglionosis^[1]. IC50 & Target:β1-integrin^[1] In Vitro:Endothelin-3, human, mouse, rabbit, rat (100 nM-1 μM) significantly enhances the adhesion capacity of mouse E12.5 YFP-labeled enteric neural crest cells cultured on fibronectin, increases the number and size of focal adhesions, and promotes the formation of lamellipodia^[1].