2-Hydroxysaclofen
CAS No. : 117354-64-0
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| Cat. No. : | HY-100812 |
| M.Wt: | 265.71 |
| Formula: | C9H12ClNO4S |
| Purity: | >98 % |
| Solubility: | H2O : 50 mg/mL (ultrasonic;adjust pH to 11 with 1 M NaOH) |
2-Hydroxysaclofen is a potent γ-amino-butyric-acid-B (GABAB) receptor antagonist. 2-Hydroxysaclofen can abolish nicotine-induced hypolocomotor effects and increases the antinociceptive effects. 2-Hydroxysaclofen can stimulate luteinizing hormone (LH) secretion in female rats[1][2][3].
IC50 & Target: GABAB receptor[1]
In Vivo: 2-Hydroxysaclofen (0.25-1 mg/kg; IP; single dosage) abolishes nicotine hypolocomotor effects and increases the antinociceptive effects of nicotine[1].
2-Hydroxysaclofen (0.3-3 mg/kg; IP; single dosage) reduces the effects of Baclofen (a GABA receptor agonist) on d-amphetamine-induced discriminative cue[2].
2-Hydroxysaclofen (0-100 μg/2 μl; ICV; single dosage) produces a rapid elevation in the serum LH concentration in the estrogen-primed ovariectomized rat[3].
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