GW583340 (dihydrochloride)
CAS No. : 1173023-85-2
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|---|---|---|
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| Cat. No. : | HY-103439 |
| M.Wt: | 671.03 |
| Formula: | C28H27Cl3FN5O3S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
GW 583340 dihydrochloride is a potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50: 0.01 and 0.014 μM respectively). GW 583340 dihydrochloride reverses ABCG2- and ABCB1-mediated drug resistance. GW 583340 dihydrochloride has anti-cancer activity[1][2][3]. In Vitro:GW 583340 dihydrochloride (5 μM) decreases the IC50 values of Mitoxantrone in inhibition of ABCG2-482-R2 and ABCG2-482-T7 cell lines[1]. GW 583340 dihydrochloride (2.5 and 7.5 μM, 24 h) increases in ROS accumulation in both SUM149 and SUM190 cells, and induces cell apoptosis[2]. GW 583340 dihydrochloride (0-10 μM) reduces the colony formation in SCCF1 cells and CatMC cells[3].
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