BRL-15572 (hydrochloride)
CAS No. : 1173022-77-9
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| Cat. No. : | HY-13200A |
| M.Wt: | 443.41 |
| Formula: | C25H28Cl2N2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
BRL-15572 hydrochloride is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 hydrochloride could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses[1].
IC50 & Target: h5-HT1D[1]
In Vitro: BRL-15572 has 60-fold higher affinity for h5-HT1D (pKi=7.9) than 5-HT1B receptors on human receptors expressed in CHO cells[1].
BRL-15572 (0.1 nM-10 μM) stimulates [35S]GTPγS binding in CHO cell membranes expressing h5-HT1B and h5-HT1D receptors[1].
In Vivo: BRL-15572 prevents (-)-epicatechin-induced antinociception in the formalin test[2].
BRL-15572 (0.3-100.0 mg/kg; i.p.) is inactive and BRL-15572 (0.1-10 mg/kg; i.p.) has no effect on body temperature the guinea pig[3].
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