Oxacillin (sodium salt)
CAS No. : 1173-88-2
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| Cat. No. : | HY-B0925 |
| M.Wt: | 423.42 |
| Formula: | C19H18N3NaO5S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Oxacillin sodium salt is an orally active synthetic penicillin with good bactericidal activity against staphylococci and other gram-positive pathogens[1].
In Vitro: Oxacillin inhibits gram positive pathogens with MICs of 0.05, 0.09, 0.32 and 0.80 μg/mL against group A streptococci, Pneutnococci, susceptible staphylococci and penicillin-resistant staphylococci, respectively[1].
The Oxacillin-resistant strains are highly resistant to other penicillins[1].
In Vivo: Oxacillin (50-800 mg/kg; s.c.; once) shows curative dose (CD50) of 253.3 mg/kg in mice infected with Staphylococcus aureus Evans. The oral CD50 of Oxacillin is 187.2 mg/kg[2].
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