NS-3-008 (hydrochloride)
CAS No. : 1172854-54-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $120 | In-stock |
| 25mg | $240 | In-stock |
| 50mg | $360 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-120897 |
| M.Wt: | 269.81 |
| Formula: | C14H24ClN3 |
| Purity: | >98 % |
| Solubility: | H2O : 125 mg/mL (ultrasonic);DMSO : 125 mg/mL (ultrasonic) |
NS-3-008 hydrochloride is an orally active transcriptional inhibitor of G0/G1 switch 2 (G0s2) with an IC50 of 2.25 μM. NS-3-008 hydrochloride can be used for chronic kidney disease[1]. IC50 & Target: IC50: 2.25 μM (G0s2)[1] In Vitro: NS-3-008 binds to Hsd17b4; knockdown of Hsd17b4 decreased G0s2 mRNA levels, whereas overexpression of Hsd17b4 induced G0s2 mRNA expression. The inhibitory effects of NS-3-008 are blocked by knockdown of Hsd17b4 or deletion of the Stat5 binding site in the G0s2 promoter. NS-3-008 decreases the nuclear phosphorylation of Stat5[1]. In Vivo: NS-3-008 (5 mg/kg; oral administration; daily; for 4 weeks; wild-type 5/6Nx mice) treatment results in decreased levels of G0s2 and Ccl2 mRNA in the kidneys. The phosphorylation of Stat5 and p65 protein is decreased, and SUN concentrations and renal caspase 3/7 activity decreased in 5/6Nx mice treated with NS-03-08. The F4/80-positive area and F4/80 protein levels are decreased in 5/6Nx mice treated with NS-3-008[1].
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Inquiry Information- Product Name:
- NS-3-008 (hydrochloride)
- Cat. No.:
- HY-120897
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