Soyasaponin Aa

Soyasaponin Aa is a soyasaponin that can be found in soy. Soyasaponin Aa suppresses PPARγ transcriptional activity, reduces PPARγ and C/EBPα expression, inhibits adipocyte differentiation and lipid accumulation, and reduces adipogenic marker gene expression. Soyasaponin Aa reduces hydrogen peroxide-induced reactive oxygen species (ROS) production and malondialdehyde levels. Soyasaponin Aa exhibits cellular antioxidant activity. Soyasaponin Aa can be used for the research of obesity^[1]. In Vitro:Soyasaponin Aa (12.5-200 μM; 24 h) shows no significant cytotoxicity toward 3T3-L1 preadipocytes^[1].
Soyasaponin Aa (25-100 μM; 8 days) dose-dependently inhibits lipid accumulation during 3T3-L1 adipocyte differentiation, leaving 75% of control lipid content remaining at 100 μM^[1].
Soyasaponin Aa (50-100 μM; 8 days) downregulates PPARγ and C/EBPα mRNA expression in fully differentiated 3T3-L1 adipocytes, with statistically significant suppression observed at 100 μM^[1].
Soyasaponin Aa (50-100 μM; 8 days) downregulates the mRNA expression of adipogenic marker genes (adiponectin, ADD1/SREBP1c, aP2, Fas, resistin) in fully differentiated 3T3-L1 adipocytes^[1].
Soyasaponin Aa (50-100 μM; 8 days) significantly suppresses PPARγ and C/EBPα protein expression in fully differentiated 3T3-L1 adipocytes^[1].
Soyasaponin Aa (25-100 μM; 24 h) significantly inhibits PPARγ transcriptional activity in HEK 293T cells^[1].
Soyasaponin Aa (25-400 μg/mL; 24 h) exhibits no cytotoxicity to human HepG2 cells at concentrations up to 100 μg/mL^[2].
Soyasaponin Aa (100 μg/mL; 24 h) protects human HepG2 cells from hydrogen peroxide-induced apoptotic morphological changes^[2].
Soyasaponin Aa (100 μg/mL; 24 h) reduces hydrogen peroxide-induced ROS generation in human HepG2 cells, lowering ROS content to 58.7%^[2].
Soyasaponin Aa (100 μg/mL; 24 h) reduces hydrogen peroxide-induced MDA levels and increases SOD, GSH-Px, and CAT antioxidant enzyme activities in human HepG2 cells^[2].