HO-3867


CAS No. : 1172133-28-6

1172133-28-6
Price and Availability of CAS No. : 1172133-28-6
Size Price Stock
5mg $100 In-stock
10mg $160 In-stock
25mg $320 In-stock
50mg $510 In-stock
100mg $810 In-stock
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Cat. No. : HY-100453
M.Wt: 464.55
Formula: C28H30F2N2O2
Purity: >98 %
Solubility: DMSO : ≥ 32 mg/mL (68.88 mM)
Introduction of 1172133-28-6 :

HO-3867 is a selective and potent STAT3 inhibitor and shows good antitumor. In Vitro: HO-3867 exhibit minimal toxicity toward noncancerous cells and tissues but induce apoptosis in ovarian cancer cells. HO-3867 inhibit cell migration/invasion and survival by inhibiting STAT3 phosphorylation[1]. BRCA-mutated ovarian cancer cells treated with HO-3867 exhibited a significant degree of apoptosis with elevated levels of cleaved caspase-3, caspase-7 and PARP[2]. HO-3867 shows good antitumor activity at the concentration of 2 μmol/L in PANC-1 and BXPC-3 cells. Importantly, it is also found that HO-3867 treatment significantly induced reactive oxygen species (ROS) production in human pancreatic cancer cell lines, inducing PANC-1 and BXPC-3 cells[3].

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