Size | Price | Stock |
---|---|---|
5mg | $100 | In-stock |
10mg | $160 | In-stock |
25mg | $320 | In-stock |
50mg | $510 | In-stock |
100mg | $810 | In-stock |
200 mg | Get quote | |
500 mg | Get quote | |
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Cat. No. : | HY-100453 |
M.Wt: | 464.55 |
Formula: | C28H30F2N2O2 |
Purity: | >98 % |
Solubility: | DMSO : ≥ 32 mg/mL (68.88 mM) |
HO-3867 is a selective and potent STAT3 inhibitor and shows good antitumor. In Vitro: HO-3867 exhibit minimal toxicity toward noncancerous cells and tissues but induce apoptosis in ovarian cancer cells. HO-3867 inhibit cell migration/invasion and survival by inhibiting STAT3 phosphorylation[1]. BRCA-mutated ovarian cancer cells treated with HO-3867 exhibited a significant degree of apoptosis with elevated levels of cleaved caspase-3, caspase-7 and PARP[2]. HO-3867 shows good antitumor activity at the concentration of 2 μmol/L in PANC-1 and BXPC-3 cells. Importantly, it is also found that HO-3867 treatment significantly induced reactive oxygen species (ROS) production in human pancreatic cancer cell lines, inducing PANC-1 and BXPC-3 cells[3].
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