LCAHA
CAS No. : 117094-40-3
(Synonyms: LCA hydroxyamide)
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $170 | In-stock |
| 25mg | $360 | In-stock |
| 50mg | $580 | In-stock |
| 100mg | $930 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-120458 |
| M.Wt: | 391.59 |
| Formula: | C24H41NO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 45 mg/mL (ultrasonic) |
LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a[1]. In Vitro: LCAHA inhibits HCT116wt and HCT116 p53-/- colon cancer cells viability with GI50s of 0.87±0.09 and 0.96±0.29μM, respectively, and the LD50s of 27.8±3.9 and 26.5±0.1μM, respectively[1].
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