Scutellarein tetramethyl ether


CAS No. : 1168-42-9

(Synonyms: 4',5,6,7-Tetramethoxyflavone)

1168-42-9
Price and Availability of CAS No. : 1168-42-9
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5mg $220 In-stock
10mg $330 In-stock
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Cat. No. : HY-N4314
M.Wt: 342.34
Formula: C19H18O6
Purity: >98 %
Solubility: DMSO : 83.33 mg/mL (ultrasonic)
Introduction of 1168-42-9 :

Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) is a bioactive compound extracted from Eupatorium odoratum. Scutellarein tetramethyl ether exhibits anti-inflammatory, antibacterial, pro-coagulant, and anti-tumor activities. Scutellarein tetramethyl ether exerts its anti-inflammatory effects by modulating the NF-κB pathway and regulates bacterial resistance through the inhibition of efflux pumps. Additionally, Scutellarein tetramethyl ether accelerates coagulation time via the endogenous coagulation pathway. Studies have shown that Scutellarein tetramethyl ether can effectively inhibit the growth of the liver cancer cell line HepG2 (IC50= 20.08 μg/mL)[1][2][3][4]. In Vitro:Scutellarein tetramethyl ether (50 and 100 μM; 1 h) inhibits the expression of COX-2 and iNOS in RAW 264.7 cells induced by LPS (HY-D1056)[1].
Scutellarein tetramethyl ether (10-100 μM; 1 h) reduces the activity of NF-κB promoter in transiently transfected RAW 264.7 cells in a dose-dependent manner[1].

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