Nexopamil (racemate)


CAS No. : 116759-35-4

116759-35-4
Price and Availability of CAS No. : 116759-35-4
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Cat. No. : HY-101727
M.Wt: 404.59
Formula: C24H40N2O3
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 116759-35-4 :

Nexopamil racemate is the racemate of Nexopamil. Nexopamil is a combined Ca2+/5-HT2 antagonist on thrombus formation in vivo and on platelet aggregation in vitro. IC50 & Target: Ca2+/5-HT2[1] In Vitro: Serotonin-induced platelet aggregation in dog platelet-rich plasma (PRP) in vitro is most potently inhibited by Nexopamil (IC50 81 nM) [1]. In Vivo: Nexopamil (0.05 mg/kg) completely abolishes cyclic flow reductions (CFRs) during the first 30 min after application without significantly altering hemodynamics[1].

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