H-9 (Dihydrochloride)
CAS No. : 116700-36-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $75 | In-stock |
| 10mg | $118 | In-stock |
| 25mg | $240 | In-stock |
| 50mg | $390 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-100923 |
| M.Wt: | 324.23 |
| Formula: | C11H15Cl2N3O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
H-9 Dihydrochloride is a PKA (protein kinase) inhibitor. H-9 Dihydrochloride (10 μM) significantly reduces the excitatory response to 5-HT. H-9 Dihydrochloride also has a direct effect on pharyngeal activity. H-9 Dihydrochloride inhibits signal-transduction and cell growth in EGF (epidermal growth factor)-dependent epithelial cell lines[1][2][3].
In Vitro: H-9 Dihydrochloride significantly inhibits A431 cells[1].
H-9 Dihydrochloride inhibits more effectively cyclic nucleotide-dependent protein kinases than other kinases[1].
In Vivo: H-9 Dihydrochloride microperfusion (100 μM) prevents picrotoxin seizures in 50% of the animals and significantly reduced the mean number of seizures and mean seizure duration[2].
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