PF-4618433
CAS No. : 1166393-85-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $500 | In-stock |
| 50mg | $820 | In-stock |
| 100mg | $1350 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-18312 |
| M.Wt: | 445.52 |
| Formula: | C24H27N7O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
PF-4618433 is a potent and selective PYK2 inhibitor, with an IC50 of 637 nM. PF-4618433 may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects and for targeted bone regeneration[1][2].
IC50 & Target: IC50: 637 nM (PYK2)[1]
In Vitro: PF-4618433 (0.1-1.0 μM; 7 days) promotes osteogenesis of hMSC cultures. PF-4618433 increases in both alkaline phosphatase (ALP) activity and mineralization in a dependent manner[1].
PF-4618433 (0.1-0.3 μM; 24 hours) enhances osteoblast proliferation[2].
PF-4618433 (0.0125-0.3 μM; 14 or 21 days) enhances calcium deposition at the concentrations of 0.1 and 0.3 μM[2].
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