ML 145
CAS No. : 1164500-72-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $132 | In-stock |
| 10mg | $198 | In-stock |
| 25mg | $337 | In-stock |
| 50mg | $550 | In-stock |
| 100mg | $770 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-107536 |
| M.Wt: | 482.57 |
| Formula: | C24H22N2O5S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
ML 145 is a selective and competitive human GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM. ML 145 has over 1000-fold more selective for GPR35 compared to GPR55 (IC50/EC50=21.7 μM)[1]. ML 145 has no significant activity for GPR35 at either rodent ortholog[2].
IC50 & Target: IC50/EC50: 20.1 nM (GPR35), 21.7 μM (GPR55)[1]
In Vitro: ML 145 (10 μM) also fully blocks internalization of human FLAG-GPR35-eYFP in response to varying concentrations of Zaprinast, Cromolyn disodium, and Pamoate[2].
ML 145 is either without effect (mouse) or displays only a small and apparently noncompetitive inhibitory effect (rat) at the rodent orthologs[2].
ML 145 acts as a competitive antagonist for a number of agonists at human GPR35 and has an IC50 value against EC80 concentrations of various GPR35 agonists in the region of 20 nM[1].
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