Sal003
CAS No. : 1164470-53-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $83 | In-stock |
| 10mg | $130 | In-stock |
| 25mg | $240 | In-stock |
| 50mg | $356 | In-stock |
| 100mg | $528 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-15969 |
| M.Wt: | 463.21 |
| Formula: | C18H15Cl4N3OS |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Sal003 is a potent, specific and cell-permeable inhibitor of the eukaryotic translation initiation factor 2α (eIF2α) phosphatase. Sal003 is a derivative of salubrinal[1].
IC50 & Target: eIF2α phosphatase[1]
In Vitro: Sal003 (20 μM; 1-12 hours) sharply increases eIF2α phosphorylation in mouse embryonic fibroblasts (MEFs)[2].
Eukaryotic translation initiation factor 2α (eIF2α) phosphorylation by Sal003 (10 μM; 1 hour) enhances subtilase cytotoxin (SubAB)-induced apoptotic signaling[1].
Sal003 promotes eIF2α phosphorylation leads to impairment of synaptic plasticity and memory[1].
In Vivo: Sal003 (20Μm; intrahippocampal injection; 8 minutes) impairs contextual memory in vivo[1].
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