Naftopidil (hydrochloride)
CAS No. : 1164469-60-6
(Synonyms: KT-611 (hydrochloride); BM-15275 (hydrochloride))
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| Cat. No. : | HY-B0391B |
| M.Wt: | 428.95 |
| Formula: | C24H29ClN2O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Naftopidil hydrochloride (KT-611 hydrochloride) is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil hydrochloride has antiproliferative effects. Naftopidil hydrochloride can be used for the research of prostate hyperplasia[1].
In Vitro: Naftopidil hydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma[2].
Naftopidil hydrochloride (10 μM for PCa cells, 0.1-10 μM for PrSC; 3 days) shows growth inhibitory effects on PCa cells and PrSC[2].
Naftopidil hydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increases the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC[2].
In Vivo: Naftopidil hydrochloride (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model[2].
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