Fargesone A
CAS No. : 116424-69-2
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| Cat. No. : | HY-N3891 |
| M.Wt: | 372.41 |
| Formula: | C21H24O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Fargesone A is a potent and selective FXR agonist. Fargesone A shows anti-inflammatory activity[1].
IC50 & Target:FXR[1]
In Vitro:Fargesone A (10 μM; 24 h) alleviates hepatocyte disorders in an FXR-dependent manner in human liver WRL68 cells[1].
Agonistic activity of Fargesone A is through direct interaction with FXR[1].
In Vivo:Fargesone A (3 and 30 mg/kg; i.p.; daily for 7 days) significantly ameliorates pathological features in bile duct ligation (BDL)-induced chronic liver fibrosis mouse model[1].
Pharmacokinetics parameters of Fargesone A in mice
| t1/2 (h) | Tmax (h) | Cmax (ng/mL) | AUC0-t (ng/mL*h) | AUC0-inf (ng/mL*h) | MRT0-inf (h) | F (%) | |
| i.v. (5 mpk) | 0.68±0.1 | - | 941±57 | 469±13 | 471±14 | 0.43±0.13 | - |
| p.o. (10 mpk) | 0.33±0.04 | 0.25±0.00 | 104±16 | 101±32 | 102±32 | 0.58±0.07 | 10.8±3.2 |
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