NSC-370284
CAS No. : 116409-29-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $320 | In-stock |
| 50mg | $540 | In-stock |
| 100mg | $940 | In-stock |
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| Cat. No. : | HY-122258 |
| M.Wt: | 387.43 |
| Formula: | C21H25NO6 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
NSC-370284 is a selective inhibitor of ten-eleven translocation 1 (TET1) and 5-hydroxymethylcytosine (5hmC). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5[1]. IC50 & Target:5-hydroxymethylcytosine (5hmC)[1] In Vitro:NSC-370284 (0-500 nM; 24 h or 48 h) inhibits the viability of MONOMAC-6, THP-1, KOCL-48 and KASUMI-1 acute myeloid leukemia (AML) cells via targeting STAT3/5. NSC-370284 significantly down-regulates the level of TET1 transcription[1]. In Vivo:NSC-370284 (2.5?mg/kg; i.p., once daily for 10 days) improves the pathological morphologies in peripheral blood (PB), bone marrow (BM), spleen, and liver tissues in MLL-AF9 acute myeloid leukemia (AML) mice model[1].
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