Fumonisin B1
CAS No. : 116355-83-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $219 | In-stock |
| 5mg | $780 | In-stock |
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| Cat. No. : | HY-N6719 |
| M.Wt: | 721.83 |
| Formula: | C34H59NO15 |
| Purity: | >98 % |
| Solubility: | H2O : 16.67 mg/mL (ultrasonic) |
Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin[1][2].
IC50 & Target: Sphingosine N-acyltransferase[2]
In Vitro: Fumonisin B1 alters the gene expression and signal transduction pathways in monkey kidney cells[3].
Fumonisin B1 increases the initial disruption of sphingolipid metabolism and the accumulation of sphinganine in LLC-PK1 kidney cells, causes DNA damage of apoptotic type in rat astrocytes[3].
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