VU0361737
CAS No. : 1161205-04-4
(Synonyms: ML-128)
| Size | Price | Stock |
|---|---|---|
| 10mg | $30 | In-stock |
| 25mg | $66 | In-stock |
| 50mg | $100 | In-stock |
| 100mg | $150 | In-stock |
| 250mg | $302 | In-stock |
| 500mg | $453 | In-stock |
| 1g | $680 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-14418 |
| M.Wt: | 262.69 |
| Formula: | C13H11ClN2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
VU0361737 (ML-128) is a potent, selective and CNS penetrant positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4 PAM), with EC50s of 240 nM and 110 nM for human and rat mGluR4 receptors, respectively. VU0361737 has neuroprotective effect. VU0361737 is potential for Parkinson's disease research[1][2].
IC50 & Target: EC50: 240 nM (human mGluR4), 110 nM (rat mGluR4)[1]
In Vitro: VU0361737 displays weak activity at mGlu5 and mGlu8 receptors and inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors[1].
VU0361737 (1-10 μM) partially attenuates the Staurosporine (HY-15141)- and Doxorubicin (HY-15142)-evoked cell death on human neuroblastoma SH-SY5Y cells[3].
In Vivo: VU0361737 exhibits terminal elimination half-lives (rat 1.9 h) due to high plasma clearance (894 mL/min/kg) following Intraperitoneal injection ( rat 10 mg/kg)[1].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- VU0361737
- Cat. No.:
- HY-14418
- Quantity:
Your information is safe with us.