Pyr3
CAS No. : 1160514-60-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $88 | In-stock |
| 10mg | $132 | In-stock |
| 25mg | $275 | In-stock |
| 50mg | $462 | In-stock |
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| Cat. No. : | HY-108465 |
| M.Wt: | 456.63 |
| Formula: | C16H11Cl3F3N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 125 mg/mL |
Pyr3 is a selective inhibitor of transient receptor potential canonical channel 3 (TRPC3), with an IC50 of 700 nM for TRPC3-mediated Ca2+ influx. IC50 & Target: IC50: 700 nM (TRPC3)[1]. In Vitro: Pyr3 selectively and directly inhibits TRPC3 channels among TRPC family members. Application of Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner with the IC50 value of 700 nM. Pyr3 becomes apparent at 0.3 μM, and is almost complete at 3 μM. Interestingly, Ca2+ influx is inhibited by Pyr3 in cells co-expressing TRPC3 plus TRPC6 but not in cells coexpressing TRPC1 plus TRPC5. The Ang II-induced NFAT translocation is suppressed by Pyr3, but weakly by Pyr2 in a concentration-dependent manner (IC50 value was 0.05 μM for Pyr3 and 2 μM for Pyr2)[1].
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