Succinylsulfathiazole

Succinylsulfathiazole (Succinylsulphathiazole) is a long-acting sulfonamide antibiotic with localized gut-specific antibacterial activity and is orally active. Succinylsulfathiazole inhibits bacterial folate synthesis, reduces coliform counts, suppresses intestinal bacterial growth and vitamin biosynthesis, and depletes gut folate-producing bacteria. Succinylsulfathiazole modulates hepatic mTOR signaling, diminishes cecal fermentation, decreases hepatic folate levels and total folate excretion, elevates nitrogen excretion and reduces the fermentability of certain dietary fibers. Succinylsulfathiazole induces folate deficiency and triggers biotin- and folate-related nutritional deficiency symptoms in rats and C57BL/6 mice^[1][2][3]. In Vivo:Succinylsulfathiazole (2%; 119 days) causes a significant, variable reduction in fecal coliform counts but no significant changes in total aerobic organisms, total anaerobic organisms, or anaerobic spore counts in Sunny Hill strain piebald rats^[3].
Succinylsulfathiazole (2%) reduces fecal excretion of biotin, folic acid, and pantothenic acid compared to unsupplemented stock or purified diets in Sunny Hill strain piebald rats^[3].
Succinylsulfathiazole (2%; 3 days) reduces fecal coliform counts, with no significant changes in total aerobic organisms, total anaerobic organisms, or anaerobic spore counts in Albino Farms strain rats^[3].
Succinylsulfathiazole (1%; oral consumption; daily; 21 weeks) modulates key components of the PI3K/AKT/mTOR signaling pathway and energy metabolism regulators in C57BL/6 mouse liver (with differential effects on REDD1 expression in folate adequate vs. depleted mice)^[1].
Succinylsulfathiazole (5 g/kg; oral; ad libitum; 27-29 days) reduces fecal folate excretion, lowers liver folate stores, decreases markers of bacterial growth, and alters cecal short-chain fatty acid production in folate-depleted Sprague-Dawley rats during folate repletion^[2].
Succinylsulfathiazole (2% w/w; oral; continuous feeding; 119 days) reduces fecal coliform counts, lowers fecal biotin and folic acid excretion, and induces leukopenia^[3].
Succinylsulfathiazole (0.5-2% w/w; oral; continuous feeding) reduces fecal coliform counts^[3].