All-trans-retinal
CAS No. : 116-31-4
| Size | Price | Stock |
|---|---|---|
| 1g | $36 | In-stock |
| 5g | $128 | In-stock |
| 10g | $246 | In-stock |
| 25g | $602 | In-stock |
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| Cat. No. : | HY-W004500 |
| M.Wt: | 284.44 |
| Formula: | C20H28O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
All-trans-retinal is an vitamin A metabolite in the retina, and is produced following photo-isomerization of the visual chromophore 11-cis-Retinal. All-trans-retinal is cleared from photoreceptors by ATP-binding cassette transporter (ABCA4) and all-trans-retinol dehydrogenase (RDH). All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis[1].
In Vitro:All-trans-retinal (10-30 μM; 16 h) displays a dose-dependent toxicity which included the morphological disruption of ARPE-19 cells and a decrease in their viability is observed to be time-dependent measured by LDH assay[1].
All-trans-retinal (10-30 μM; 30 mim) increases the phosphorylation of p53 at Ser 46 and 8-OHdG production[1].
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