Tetradifon

Tetradifon is a broad-spectrum organochlorine insecticide and an inhibitor of the mitochondrial oligomycin sensitivity conferring protein (OSCP), which can be used to control a variety of mites. Tetradifon inhibits energy-related activities such as ADP-stimulated respiration, DNP and Mg²⁺-stimulated ATPase, with an IC₅₀ of 4.5-27 nmoL/mg mitochondrial protein. Tetradifon exerts oligomycin-like activity by inhibiting the oxidative phosphorylation process, inducing oxidative stress and interfering with bone metabolism. Tetradifon is currently mainly used in the research of mitochondrial function regulation, bone remodeling mechanism and nephrotoxicity of environmental pollutants^{[1][2][3][4][5]}. In Vitro:Tetradifon has a biological mechanism similar to Oligomycin (HY-N6782) and can be reversed by DNP^[1]. In Vivo:Tetradifon (24.3 mg/kg; oral, 90 days) causes increased trabecular thickness and elevated serum alkaline phosphatase in female rats, and induces glomerular sclerosis and renal interstitial fibrosis in rats^[3].