AMG9678
CAS No. : 1159997-27-9
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| Cat. No. : | HY-104062 |
| M.Wt: | 416.36 |
| Formula: | C20H18F6N2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
AMG9678 is a potent, selective, orally active antagonist of TRPM8 with an IC50 of 31.2 nM[1].
IC50 & Target: IC50: 31.2 nM (TRPM8 Menthol (Cold)), 0.6 µM (TRPA1 (AITC))[1]
In Vitro: AMG9678 potently inhibits the menthol and cold-induced increase in intracellular calcium in cells expressing rat TRPM8, the plasma half-life (T1/2) in rats is 7.6 h[1].
In Vivo: AMG9678 (0-100 mg/kg; p.o.; once) produces a significant and somewhat dose-dependent decrease in body temperature (Tb) in rats[1].
AMG9678 (30 mg/kg; p.o.; once daily for 4 consecutive days) decreases reduced body temperature after repeated dosing in rats[1].
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