AMG8788
CAS No. : 1159996-43-6
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| Cat. No. : | HY-104061 |
| M.Wt: | 414.40 |
| Formula: | C23H18F4N2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
AMG8788 is a potent, selective, orally active antagonist of TRPM8 with an IC50 of 63.2 nM[1]. IC50 & Target: 63.2 nM (TRPM8 Menthol (Cold)), 1 µM (TRPA1 (AITC))[1] In Vitro: AMG8788 potently inhibits the menthol and cold-induced increase in intracellular calcium in cells expressing rat TRPM8, the plasma half-life (T1/2) in rats is 6.7 h[1]. In Vivo: AMG8788 (30 mg/kg; p.o.; once) elicits a transient decrease in body temperature (Tb) in rats[1].
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